"And I will cause hostility between you (talking to Satan/the serpent) and the woman,
and between your (the Devil) offspring (and unbelievers) and her offspring ( meaning Christ).
He will strike your head (a fatal blow), and you will strike his heel (suffer on the cross...which is the sacrifice Christ made as part of God's redemptive plan)."
I added explanation in parenthesis. Paul refers to the struggle between Satan and Christ in Romans 16.20.
Also note: So you see from the earliest writings of the Bible, God, His Holy Spirit and a Savior are referenced.